The value of plasma ADAMTS4 in evaluating the stability of carotid plaque
10.3760/cma.j.issn.1007-631X.2017.12.017
- VernacularTitle:血浆ADAMTS4在颈动脉斑块稳定性评估中的价值
- Author:
Qinqin TIAN
1
;
Tian DU
;
Jie HU
;
Peilu SHI
;
Wenkai CHANG
;
Yuwen WANG
;
Haifeng LI
;
Honglin DONG
Author Information
1. 山西医科大学第二医院血管外科
- Keywords:
Carotid stenosis;
Plaque,atherosclerotic;
ADAMTS4
- From:
Chinese Journal of General Surgery
2017;32(12):1043-1046
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the level of plasma ADAMTS4 and the vulnerability of carotid atherosclerotic plaque in patients with carotid artery stenosis and the clinical value of evaluating the vulnerability of the carotid atherosclerotic plaque.Methods 60 patients with carotid artery stenosis were divided into stable plaque group and vulnerable plaque group according to the histopathological typing after carotid endarterectomy (CEA).30 patients who had atherosclerosis but no carotid plaque formation served as control.Using ELISA to measure the level of plasma ADAMTS4.Results The level of plasma ADAMTS4 was significantly higher in the vulnerable-plaque group (112.74 ± 17.47) ng/ml compared with the stable plaque group (56.67 ± 22.14)ng/ml and the control group (56.67 ± 22.14)ng/ ml,P ＜ 0.001.Logistic analysis showed that high level of plasma ADAMTS4 was risk factor for vulnerability of carotid atherosclerotic plaque (P ＜ 0.05,OR =8.240,95 ％ CI:1.512-22.915).ROC curve showed that ADAMTS4 =100.935 ng/ml could accurately predict significant vulnerability with accuracy of 94.3％.Conclusion ADAMTS4 is an effective,sensitive and non-invasive biomarker to evaluate the vulnerability of carotid atherosclerotic plaque.
