Ultrahistopathological features of six cases of symmetrical acrokeratoderma under transmission electron microscope
10.3760/cma.j.issn.0412-4030.2018.02.010
- VernacularTitle:六例对称性肢端角化病的透射电镜观察
- Author:
Ying ZHOU
1
;
Sijie WANG
;
Yayun WU
;
Shijie LI
;
Zhaojun LI
;
Guoxue ZHANG
;
Yiming FAN
Author Information
1. 广东医科大学附属医院皮肤科
- Keywords:
Microscopy,electron,transmission;
Symmetrical acrokeratoderma;
Keratin filaments;
Keratohyalin granules;
Membrane-coating granules
- From:
Chinese Journal of Dermatology
2018;51(2):131-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate ultrahistopathological features of symmetrical acrokeratoderma.Methods Biopsy specimens were obtained from skin lesions and perilesional normalappearing skin of 6 patients with symmetrical acrokeratoderma,as well as from normal skin of 3 healthy volunteers.Then,these skin specimens were subjected to transmission electron microscopy (TEM).Results TEM showed obviously thickened stratum corneum,irregular morphology of keratinocytes and discontinuous cornified envelope.Aggregation and abnormal arrangement of keratin filaments occurred in all epidermal layers.Many vacuoles of different sizes were observed in the transitional zone between the stratum corneum and stratum granulosum.Hypogranulosis,abnormal shape and different sizes of keratohyalin granules,and reduction of membrane-coating granules were found in the stratum granulosum.Increased melanocytes with a large number of stage Ⅳ melanosomes in the cytoplasm were observed in the basal layers.Moreover,there was infiltration of a few lymphocytes in the superficial dermis.Perilesional normal-appearing skin tissues showed similar but milder ultrastructural changes.Conclusion Abnormal metabolism of keratins,epidermal differentiation complex proteins and lipids may exist in skin lesions of symmetrical acrokeratoderma,which may contribute to epidermal thickening and impairment of skin barrier function.
