Chemical constituents from Pterocephalus hookeri and their neuroprotection activities
10.3969/j.issn.1001-1528.2018.06.021
- VernacularTitle:翼首草化学成分及其神经保护活性
- Author:
Gong-Quan LI
1
;
Dong-Lai SHENG
Author Information
1. 上海市宝山区精神卫生中心
- Keywords:
Pterocephalus hookeri (C.B.Clarke) Hoeck;
chemical constituents;
isolation and identification;
neuroprotective activities
- From:
Chinese Traditional Patent Medicine
2018;40(6):1329-1335
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Pterocephalus hookeri (C.B.Clarke) Hoeck and their neuroprotection activities.METHODS The 95％ ethanol extract from P.hookeri was isolated and purified by Sephadex LH-20,DM-130 macroporous resin,silica and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The neuroprotection activities were studied by establishment of Parkinson's disease model of genetically modified zebrafish.RESULTS Nine compounds were isolated and identified as triplostoside A (1),cantleyoside (2),sylvestroside Ⅰ (3),sylvestroside Ⅲ dimethyl acetal (4),sylvestroside Ⅲ (5),laciniatoside Ⅰ-7-dibutyl acetal (6),laciniatoside Ⅰ (7),laciniatoside Ⅱ (8),sylvestroside Ⅳ (9).The n-BuOH fraction of P.hookeri had good performance on neuroprotection in hydrogen peroxide model.CONCLUSION Compound 4 is isolated from this plant for the first time.P.hookeri has neuroprotection activities.
