Pharmacokinetic behaviors of four constituents in sugar-free Xinnaosu Granules in rat plasma
10.3969/j.issn.1001-1528.2018.06.011
- VernacularTitle:心脑苏颗粒(无糖型)中4种成分在大鼠血浆中的药动学行为
- Author:
Jun XIE
1
;
Zhi-Tao JIANG
;
Xue WANG
;
Xing-Yue FENG
;
Jin-Huo PAN
;
Xiao-Feng CHEN
Author Information
1. 南京中医药大学附属张家港医院
- Keywords:
sugar-free Xinnaosu Granules;
tanshinone Ⅱ A;
salvianolic acid B;
ginsenoside Rg1;
notoginsenoside R1;
pharmacokinetic behaviors;
plasma;
UHPLC-MS/MS
- From:
Chinese Traditional Patent Medicine
2018;40(6):1283-1287
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the pharmacokinetic behaviors of four constituents in sugar-free Xinnaosu Granules in rat plasma.METHODS Rats intragastrically administered with the 0.5％ CMC-Na suspension of this drug (3 g/kg) had their blood collected for the determination of plasma concentration by UHPLC-MS/MS,after which pharmacokinetic parameters were calculated by DAS2.0 software.RESULTS The plasma concentrationtime curves for tanshinone Ⅱ A,salvianolic acid B,ginsenoside Rg1,notoginsenoside R1 accorded with two compartment model,with the t1/2values of (1.68 ±0.56),(4.13 ±0.87),(3.62 ±0.87),(9.77 ±3.12) h,Tmax values of (0.51 ±0.19),(1 ±0),(6 ±0),(4.00 ±1.09) h,Cmax values of (0.42 ±0.08),(0.17 ±0.02),(0.46±0.11),(0.41 ±0.12) mg/L,respectively.CONCLUSION All the four constituents in sugar-free Xinnaosu Granules demonstrate high bioavailabilities.
