Effects of three aqueous extraction preprocessing methods on total coumarins extract of Angelicae dahuricae Radix
10.3969/j.issn.1001-1528.2018.05.011
- VernacularTitle:3种水提预处理方法对白芷总香豆素提取物的影响
- Author:
Jin-Hua CHANG
1
;
Yun LI
;
Cui-Zhe LIU
Author Information
1. 承德医学院
- Keywords:
total coumarins extract of Angelicae dahuricae Radix;
aqueous extraction preprocessing methods;
total coumarins;
imperatorin;
powder properties;
dissolution rates
- From:
Chinese Traditional Patent Medicine
2018;40(5):1065-1069
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of aqueous extraction at normal temperature,40 ℃,and water boiling on total coumarins extract of Angelicae dahuricae Radix.METHODS For the extracts Ⅰ-Ⅳ obtained by ethanol reflux extraction and three aqueous extraction preprocessing methods,respectively,UV and HPLC were adopted in the content determination of total coumarins and imperatorin,then the powder properties and dissolution rates were compared.RESULTS The contents of total coumarins in four extracts were 3.98％,6.03％,6.81％ and 4.46％,while those of imperatorin were 0.633％,0.540％,0.465％ and 0.155％,respectively.The angles of repose were 48.455°,42.587°,42.689° and 42.024° with the bulk densities of 0.214,0.324,0.316 and 0.354 g/cm3,respectively.Within 100 min,extract Ⅰ demonstrated higher moisture adsorption rate and equilibrium moisture absorption content than the other three extracts.The accumulative dissolution rates of various extracts were much higher than that of medicinal material fine powder within 120 min.CONCLUSION All the three aqueous extraction preprocessing methods can obviously improve the powder properties of total coumarins extract of A.dahuricae Radix and increase the dissolution rate of medicinal material fine powder.
