The mechanism of active ingredients in Salicornia europaea in treatment of diabetes based on pharmacological network
10.3969/j.issn.1001-1528.2018.04.007
- VernacularTitle:基于网络药理学的海蓬子活性成分抗糖尿病作用机制
- Author:
Ran-Ran WANG
1
;
Shao-Yong LI
;
Wei QIAO
;
Fang-Qin SONG
;
Hui ZHOU
;
Shan QIAO
Author Information
1. 天津医科大学药学院
- Keywords:
Salicornia europaea L.;
pharmacological network;
potential target;
diabetes
- From:
Chinese Traditional Patent Medicine
2018;40(4):802-809
- CountryChina
- Language:Chinese
-
Abstract:
AIM To develop a pharmacological network screening method in predicting the potential target,active ingredients and pathway of Salicornia europaea L.for the treatment of diabetes,and to uncover its underlying multi-component,multi-target,multi-pathway mechanism.METHODS Information about fifteen kinds of bioactive chemical constituents of Salicornia europaea L.acquired from a large amount of literature were used to predict the targets according to PharmMapper Server,and such a prediction was also subjected to the screening of the antidiabetes drug targets approved by FDA in the DrugBank database.The relevant information of potential target and pathway was obtained by MAS 3.0 biomolecule function software.Cytoscape software was used to construct the Salicornia europaea L.ingredients-targets-pathways network.RESULTS Fifteen major active ingredients of Salicornia europaea L.affecting in a total of 86 pathways (VEGF signaling pathway,Fc epsilon RI signaling pathway,T cell receptor signaling pathway,etc),including the 30 particular diabetes-related pathways of MAP2K1,MAPK,GSK3B,AKT,etc.,fully demonstrated the multi-component,multi-target,multi-pathway mechanism of Salicornia europaea L.in the treatment of diabetes and its complications,through regulating immune,lipid metabolism,inflammation,apoptosis and other processes.CONCLUSION Given the new understanding in analyzing the scientific connotation of anti-diabetes effect,and the complex system of Salicornia europaea L.,this paper highlights the direction for the next step in the validation experiment of its target and mechanism.
