Formation rules of baicalin-berberine complex
10.3969/j.issn.1001-1528.2018.03.013
- VernacularTitle:黄芩苷-小檗碱复合物的形成规律
- Author:
Yan-Li LEI
1
;
Lei SUN
;
Hong SUI
;
Wen-Ping WANG
Author Information
1. 宁夏医科大学药学院
- Keywords:
baicalin-berberine complex;
mixed decoction precipitation;
HPLC
- From:
Chinese Traditional Patent Medicine
2018;40(3):577-582
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the formation rules of baicalin-berberine complex.METHODS Under the conditions of different ratios of baicalin to berberine,heating methods and media (pH,ionic strength),the yield and composition of mixed decoction precipitation were determined by HPLC.RESULTS 0.5 g Baicalin and 1 g berberine produced the highest amount of precipitation.Higher heating temperature,nearly neutral pH (6.8) and glucose addition were beneficial to precipitate generation,in sharp contrast to NaCl addition.CONCLUSION The yield and composition of baicalin-berberine complex are mainly influenced by heating temperature and additives.
