Preparation of Guizhi Fuling transdermal patch
10.3969/j.issn.1001-1528.2018.03.012
- VernacularTitle:桂枝茯苓透皮贴剂的制备
- Author:
Su-Xiang WU
1
;
Ran YAN
;
Sen-Lin SHI
;
Wei-Hong GE
Author Information
1. 浙江中医药大学,浙江杭州310053
- Keywords:
Guizhi Fuling transdermal patch;
preparation;
paeoniflorin;
cinnamic acid;
paeonol;
in vitro transdermal permeation;
single factor test
- From:
Chinese Traditional Patent Medicine
2018;40(3):571-577
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare Guizhi Fuling transdermal patch.METHODS With kinds of pressure-sensitive adhesive and penetration enhancer,kind and consumption of solvent,drug loading as influencing factors,appearance,formability and viscidity of patch,extract dispersion as evaluation indices,single factor test was applied to optimizing the preparation.And subsequent in vitro transdermal absorption test was performed to investigate the steady-state permeation rates of paeoniflorin,cinnamic acid and paeonol onto rat skins.RESULTS The optimal conditions were determined to be Duro-Tak 87-2677 polyacrylate pressure-sensitive adhesive (matrix),1 ∶ 0.5 for ratio of extract to propanediol (solvent),3％ azone as a penetration enhancer,and 20％ for drug loading,the obtained transdermal patch demonstrated both ideal initial adhesion force and holding adhesion force.These three constituents' average transdermal rates were 34.32,1.684,72.90 μg/(cm2 · h) with the average release rates of 26.81,1.523,111.8 μg/(cm2 · h),respectively,whose in vitro transdermal permeation curves conformed to Higuchi equation.CONCLUSION Guizhi Fuling transdermal patch processed with simple and stable preparation technique exhibits good in vitro transdermal permeation performance.
