Preventive and therapeutic mechanism of the herbal pair, Scutellariae Radix and Coptidis Rhizoma on dementia-like mice induced by D-galactose
10.3969/j.issn.1001-1528.2018.03.004
- VernacularTitle:黄芩-黄连药对防治D-半乳糖痴呆小鼠的作用机制
- Author:
Chang-Hua ZHANG
1
;
Tong-Tong LIU
;
Ke-Zhong DENG
;
Ying-Chong CHEN
;
Gui-Bing LIN
;
He-Ping YE
;
Xiu-Ying TU
;
Jun-Qing SHENG
Author Information
1. 江西中医药大学药学院
- Keywords:
herbal pair of Scutellariae Radix and Coptidis Rhizoma;
D-Galactose;
dementia;
improve
- From:
Chinese Traditional Patent Medicine
2018;40(3):524-529
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the preventive effects of herbal pair,Scutellariae Radix and Coptidis Rhizoma (SC),on Alzheimer's disease (AD),and its mechanism of action.METHODS Dementia mice induced by 8-week s.i.d subcutaneous injection of D-galactose (100 mg/kg),were simultaneously given respective,intragastric administration of SC crude drug at doses of 5,10,20 g/kg,or piracetam support at 0.75 g/kg,and isometrical distilled water was applied to the mice of normal control group.The mice had their learning and memory abilities checked by Morris water maze at intervals of four weeks and eight weeks since the start of the trial,and their blood and brain tissue biochemical indices measured at the end of the test.RESULTS Significantly shortened latent period in place navigation test and the time of enter into the original platform in the space exploration test were observed in the mice treated with 4-week D-galactose and SC (P ＜0.05 或 P ＜0.01).The 8-week intervention demonstrated SC capacity in the significant promotion of T-SOD activity,decreased blood MDA levels (P ＜ 0.01)and the brain AchE levels,and increased brain GSH-Px activity (P ＜ 0.01).CONCLUSION SC increases the concentration of acetylcholine in brain tissue and protects the central nervous tissue under oxidative stress,highlighting its therapeutic effect on AD.
