Effects of Tangzhi Kangping Granules on the blood sugar and lipid in rats with disordered glucose and lipid metabolism
10.3969/j.issn.1001-1528.2018.02.004
- VernacularTitle:糖脂康平颗粒对糖脂代谢紊乱大鼠血糖血脂的作用
- Author:
Yuan LIU
1
;
Ru-Yue LI
;
Yu-Xing CHEN
;
Xue-Jun HUANG
;
Xiao-Hui ZENG
;
Dan-E HUANG
;
Hai-Ning GAN
;
Hong-Mei TANG
Author Information
1. 广州中医药大学,广东广州510405
- Keywords:
Tangzhi Kangping Granules;
diabetes;
hyperlipidemia
- From:
Chinese Traditional Patent Medicine
2018;40(2):265-270
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effects of Tangzhi Kangping Granules (Astragali Radix,Ligustri lucidi Fructus,Schisandrae chinensis Fructus,etc.) on regulating blood sugar and lipid of rats with glucose and lipid metabolism disorders.METHODS Among the seventy rats for the trial,ten rats were randomly assigned to normal control group,the other 60 rats were injected with STZ citric acid-sodium citrate solution (60 mg/kg) combined with high-fat emulsion (10 mL/kg) for 4 weeks to be the models of glucose and lipid metabolism disorders.The model rats were divided into model control group,mefformin + fenofibrate group,Xiaoke Pills + Xuezhikang group,and high,medium and low dose Tangzhi Kangping Granules groups.After 4-week intragastric administration,the rats had their levels of fasting serum glucose (GLU),triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipids (LDL-C),insulin (INS),adiponectin (ADP),leptin (Leptin),interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) measured.RESULTS Compared with the model control group,the rats in high,medium and low dose Tangzhi Kangping Granules groups displayed significantly decreased serum contents of GLU,TG and TC,lowered levels of LDL-C,ADP,Leptin,IL-6,TNF-α,and yet significantly increased levels of HDL-C and INS.CONCLUSION Tangzhi Kangping Granules,a blood sugar andlipid regulator may adjust the levels of insulin,adiponectin and leptin,and therefore improves the body's inflammatory environment to alleviate insulin resistance.
