Chemical constituents from the fruits of Evodia rutaecarpa and their biological activities
10.3969/j.issn.1001-1528.2018.01.024
- VernacularTitle:大花吴茱萸果实化学成分及其生物活性
- Author:
Wei RUI
1
;
Xu FENG
;
Fei LIU
;
Min YIN
;
Ming WANG
;
Chen-Wei TANG
;
Jin-Yue LUO
;
Qi-Zhi WANG
Author Information
1. 南京林业大学化学工程学院,江苏南京210037
- Keywords:
Evodia rutaecarpa (Juss.) Benth.;
fruits;
chemical constituents;
isolation and identification;
antitumor activity;
antifungal activity
- From:
Chinese Traditional Patent Medicine
2018;40(1):121-125
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the fruits of Evodia rutaecarpa (Juss.) Benth.and their biological activities.METHODS The ethyl acetate fraction of 80％ ethanol extract from E.rutaecarpa was isolated and purified by silica column and recrystallization,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The antitumor and antifungal activities were determined by MTT and mycelium growth method,respectively.RESULTS Ten compounds were isolated and identified as rutaecarpine (1),evodiamine (2),1-methyl-2-undecyl-4 (1H)-quinolone (3),1-methyl-2-tridecyl-4 (1H)-quinolone (4),wuchuyuamide Ⅰ (5),wuchuyuamide Ⅲ (6),wuchuyuamide Ⅳ (7),β-sitosterol (8),β-daucosterol (9),dehydroevodiamine (10).Compounds 1,2,10 had certain inhibitory effects on MDA-MB-231,LoVo,A2780 and HeLa with the IC50values of 0.65-29.45 μmol/L.Compound 1 had a certain inhibitory effect on Botrytis cinerea,Glomerella cingulata and Rhizoctonia solani with the inhibitory rates of 18.12％-49.57％.CONCLUSION Compounds 3-7 are isolated from this plant for the first time,compounds 1,2,10 have strong biological activities.
