Correlation Between Levels of N-terminal Pro-B-Type Natriuretic Peptide and Degrees of Heart Failure.
10.3904/kjim.2005.20.1.26
- Author:
Bong Geun SONG
1
;
Eun Seok JEON
;
Yong Hoon KIM
;
Min Kyung KANG
;
Joon Hyung DOH
;
Phil Ho KIM
;
Seok Jin AHN
;
Hye Lim OH
;
Hyun Joong KIM
;
Ji Dong SUNG
;
Sang Chol LEE
;
Hyeon Cheol GWON
;
June Soo KIM
;
Duk Kyung KIM
;
Sang Hoon LEE
;
Kyung Pyo HONG
;
Jeong Euy PARK
;
Soo Youn LEE
;
Jong Koo LEE
Author Information
1. Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. esjeon@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Natriuretic peptides;
Heart failure;
Myocardial ischemia
- MeSH:
Dyspnea/physiopathology;
Female;
Heart Failure, Congestive/*blood/*physiopathology;
Humans;
Male;
Middle Aged;
Nerve Tissue Proteins/*blood;
Peptide Fragments/*blood;
Prospective Studies;
*Severity of Illness Index;
Stroke Volume/physiology;
Systole/physiology;
Ventricular Dysfunction, Left/physiopathology
- From:The Korean Journal of Internal Medicine
2005;20(1):26-32
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The N-terminal fragment of pro Brain Natriuretic Peptide (NT-pro BNP) is a neuro-hormone synthesized in the cardiac ventricles in response to increased wall tension. The purpose of this study was to assess the correlation between the NT-pro BNP levels and the New York Heart Association function class (NYHA Fc) of dyspnea and echocardiographic findings for the patients who visited our cardiology departments. METHODS: From October, 2002 to April, 2003, serum NT-pro BNP levels were measured in 348 patients who visited the Samsung Medical Center and the Jong Koo Lee Heart Clinic. RESULTS: The NT-pro BNP levels were increased with the progression of NYHA Fc of dyspnea (p< 0.001 by ANOVA), the increase in the systolic left ventricular internal dimension (p< 0.05), and the decrease in the ejection fraction (p< 0.01). For the NYHA Fc I patients, the NT-pro BNP levels were positively correlated with age (p< 0.001) and left atrial size (p< 0.001). For the patients with ischemic heart disease, the NT-pro BNP levels were also positively correlated with the NYHA Fc (p< 0.001 by ANOVA). The NT-pro BNP levels were increased with the increase in the systolic (p< 0.001) and diastolic pressure (p=0.017), the left ventricular internal dimension as well as the decrease in the ejection fraction (p< 0.001). The area under the receiver operating characteristic (ROC) curve for the NT-pro BNP levels was 0.994 (95% confidence interval, 0.979-0.999), and the most reliable cut-off level for the NT-pro BNP was 293.6 pg/mL. CONCLUSION: The NT-pro BNP levels were positively correlated with the NYHA Fc of dyspnea and the systolic dysfunction for the patients who visited our cardiology departments. A 300 pg/mL value for the NT-pro BNP cut-off point appears to be a sensitive level to differentiate dyspnea originating from an ailing heart or not for the patients who visited our cardiology departments.
