Preparation of silymarin solid dispersions and dissolution rates of five constituents
10.3969/j.issn.1001-1528.2018.01.016
- VernacularTitle:水飞蓟素固体分散体的制备及5种成分的溶出度
- Author:
Xin-Rong SUN
1
;
Min-Xin ZHANG
;
Hai-Yue YANG
;
Jue WU
;
Hong-Tao SONG
;
Zhi-Hong LIU
Author Information
1. 福建中医药大学药学院
- Keywords:
silymarin;
solid dispersions;
preparation;
chemical constituents;
dissolution rates;
solvent fusion method
- From:
Chinese Traditional Patent Medicine
2018;40(1):87-92
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare silymarin solid dispersions and to evaluate the dissolution rates of five constituents.METHODS Taking F68 and PVPk30 as a combined carrier,the solid dispersions were prepared by solvent fusion method.Then the effects of combined carrier ratio and drug-carrier ratio on dissolution rates of silybin,isosilybin,silydianin,silycristin and taxifolin were investigated.RESULTS The optimal conditions were determined to be 1 ∶ 3 for combined carrier ratio,and 1 ∶ 5 for drug-carrier ratio.These five constituents displayed much higher dissolution rates in solid dispersions than those in raw medicine and physical mixture (silymarin-carrier).CONCLUSION Solid dispersions can significantly increase the dissolution rates of effective components in silymarin.
