Preparation of chrysin solid lipid nanoparticles and their pharmacokinetic behaviors
10.3969/j.issn.1001-1528.2018.01.014
- VernacularTitle:白杨素固体脂质纳米粒的制备及其药动学行为
- Author:
Jin-Zhi YANG
1
;
Wen-Xia SUN
;
Jiao-Jiao WANG
;
Feng CUI
;
Hai-Jun HAO
Author Information
1. 郑州澍青医学高等专科学校
- Keywords:
chrysin;
solid lipid nanoparticles;
preparation;
pharmacokinetics;
emulsification ultrasonication-low temperature solidification;
HPLC
- From:
Chinese Traditional Patent Medicine
2018;40(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare chrysin solid lipid nanoparticles and to evaluate their pharmacokinetic behaviors.METHODS The particle size,Zeta potential and in vitro release rate of nanoparticles prepared by emulsification uhrasonication-low temperature solidification method were determined.Twelve SD rats were randomly divided into two groups and were intragastrically given suspensions of crude drug and nanoparticles,respectively.HPLC was used for the content determination of chrysin in plasma,after which blood drug concentration-time curves were drawn,and pharmacokinetic parameters were calculated.RESULTS The obtained nanoparticles demonstrated the particle size of (207.15 ±30.59) nm,PDI of (0.224 ±0.067) and Zeta potential of (-34.8 ±5.9) mV,respectively,whose accumulative release rate reached 84.36％ within 36 h.Their Cmax [(9.04 ± 1.52) μg/mL] and AUC0～t,[(33.67 ± 3.47) μg · h/mL] were much higher than those of the crude drug (P ＜ 0.01).CONCLUSION Solid lipid nanoparticles can promote the oral absorption and bioavailability of chrysin,with significant sustained-release characteristics.
