Safflower Injection combined with alprostadil and sildenafil treats the chronic pulmonary heart disease complicated with pulmonary hypertension
10.3969/j.issn.1001-1528.2017.01.007
- VernacularTitle:红花注射液联合前列地尔和西地那非治疗慢性肺心病的肺动脉高压
- Author:
Tie-Li YANG
1
;
Xiao-Fang ZHANG
;
Sheng-Jun PAN
;
Kun CHEN
;
Jing CONG
Author Information
1. 黄淮学院附属医院
- Keywords:
Safflower Injection;
alprostadil;
sildenafil;
chronic pulmonary heart disease;
pulmonary hypertension
- From:
Chinese Traditional Patent Medicine
2017;39(1):40-46
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effect of Safflower Injection (safflower yellow) combined with alprostadil and sildenafil in the treatment of chronic pulmonary heart disease (chronic cor pulmonale) complicated with pulmonary hypertension.METHODS Two hundred and twenty-three cases of chronic pulmonary heart disease complicated with pulmonary hypertension patients were randomly divided into two groups,the control group of one hundred and eleven cases in conventional therapy plus alprostadil and sildenafil,one hundred and twelve cases in the treatment group were treated with Safflower Injection on the basis of the control group.The efficacy and side effects in two groups were observed.RESULTS The total effective rate of the treatment group was significantly higher than that of the control group.Pulmonary artery systolic pressure (SPAP),pulmonary arterial mean pressure (mPAP) and pulmonary artery diastolic blood pressure (DPAP) in two groups,compared with those before the treatment,were significantly decreased,left ventricular shoot ejection fraction (LVEF),compared with those before treatment,was significantly increased;SPAP,mPAP and DPAP of treatment group after the treatment were decreased significantly as compared with the control group,LVEF was significantly increased.Arterial partial pressure of oxygen (PaO2) and arterial oxygen saturation (SaO2) in two groups,compared with those before the treatment,were significantly increased,carbon dioxide partial pressure (PaCO2),compared with those before the treatment,was significantly decreased;after treatment in the treatment group,PaO2 was significantly increased as compared with the control group.Blood high shear viscosity,whole blood viscosity at low shear,plasma viscosity,red blood cell pressure volume and platelet aggregation rate in two groups were significantly lower than those before the treatment;whole blood high shear viscosity,whole blood viscosity of low shear,plasma viscosity and platelet aggregation rate in the treatment group,compared with the control group,were decreased significantly.High sensitive C reactive protein (hsCRP),creatine kinase (CK-MB) and cardiac troponin Ⅰ (TnⅠ) in two groups,compared with those before the treatment,were significantly reduced;after the treatment,hs-CRP,CK-MB and TnⅠ in the treatment group,compared with the control group,were decreased significantly.There was no difference in incidence of adverse reactions between the two groups.There were no significant changes in liver and renal functions before and after the treatment in two groups.CONCLUSION Safflower Injection combined with alprostadil and sildenafil in the treatment of chronic pulmonary heart disease complicated with pulmonary hypertension has a good curative effect.
