Sangtongjian Mixture ameliorates glucose and lipid metabolism in type 2 diabetic rats
10.3969/j.issn.1001-1528.2017.01.004
- VernacularTitle:桑酮碱改善2型糖尿病大鼠的糖脂代谢
- Author:
Mei-Yu KUAI
1
;
Zhi MA
;
Xin SUN
;
Qing-Hai MENG
;
Chao LIN
;
Ying LU
;
Yu LI
;
Guo-Ping PENG
;
Zhen OUYANG
;
Hui-Min BIAN
Author Information
1. 南京中医药大学药学院
- Keywords:
type 2 diabetes;
Sangtongjian Mixture (STJ);
insulin resistance;
glucose and lipid metabolism;
adiponectin;
leptin
- From:
Chinese Traditional Patent Medicine
2017;39(1):21-26
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the effects of Sangtongjian Mixture (STJ) on glucose and lipid metabolism,insulin resistance and fat cytokines in type 2 diabetic rats,and their mechanisms of action.METHODS One hundred and forty rats fed on the combination of STZ and high fat diet were established as the type 2 diabetic models.Fasting blood glucose (FBG) level reached more than 16.7 mmol/L and then the rats were randomly divided into model group,metformin (180 mg/kg) group,STJ (73.5,147 and 294 mg/kg) groups.Ten rats were set as the blank group.Each treatment group was intragastrically given the corresponding agents for twelve weeks.The fasting blood glucose levels of rats were measured once every two weeks after the administration.After a 12-week administration period,glycosylated serum protein (GSP),glycosylated hemoglobin (GHb) and lipid profile indices (TC,TG,HDL-C and LDL-C) were determined.The serum insulin level was measured by radioimmunoassay,and homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity index (ISI) were calculated.The levels of serum adiponectin and leptin were detected by ELISA.RESULTS STJ remarkably decreased the levels of FBG,GSP,GHb,TC,TG,LDL-C,leptin and HOMR-IR in type 2 diabetic rats.Furthermore,STJ also significantly increased the levels of HDL-C,adiponectin and ISI.CONCLUSION STJ can improve glucose and lipid metabolism in type 2 diabetic rats by ameliorating insulin resistance and regulating fat cytokine levels.
