The expression and prognostic significance of microRNA-34a in Uygur and Han patients with chronic lymphocytic leukemia in Xinjiang Uygur Autonomous Region in China
10.3760/cma.j.issn.0578-1426.2018.12.009
- VernacularTitle:微RNA-34a在新疆维吾尔族和汉族慢性淋巴细胞白血病患者的表达及其预后意义
- Author:
Hong LIU
1
;
Xiaomin WANG
;
Min MAO
;
Ling FU
;
Qin HUANG
;
Yilin WANG
;
Yichun WANG
;
Zengsheng WANG
;
Yan LI
Author Information
1. 新疆维吾尔自治区人民医院血液病科
- Keywords:
Leukemia,lymphocytic,chronic,B-cell;
Uygur;
microRNA-34a;
Prognosis
- From:
Chinese Journal of Internal Medicine
2018;57(12):922-925
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the expression of microRNA-34a (miR-34a) in patients with chronic lymphocytic leukemia (CLL) in Xinjiang Uygur and Han nationalities and its prognostic significance. Our data showed that miR-34a expression in Uygur and Han CLL patients was significantly higher than that in their respective healthy controls, while miR-34a levels were similar between Uygur and Han patients. By comparing with known prognostic factors, receiver operating characteristic (ROC) curves showed that miR-34a was a good predictive factor for the prognosis of CLL (demarcation value was 3.567 6). Survival analysis was further performed according to miR-34a expression level, that low expression of miR-34a translated into poor prognosis.
