The association of lipid profile and bleeding in patients with minor stroke or transient ischemic attack on antiplatelet therapy: subgroup analysis of CHANCE
10.3760/cma.j.issn.0578-1426.2018.10.006
- VernacularTitle:血脂谱对急性轻型卒中/短暂性脑缺血发作患者抗血小板治疗后出血风险的影响: CHANCE研究的亚组分析
- Author:
Jiejie LI
1
;
Hongqiu GU
;
Yujing PENG
;
Xingquan ZHAO
;
Yilong WANG
;
Xia MENG
;
Liping LIU
;
Yongjun. WANG
Author Information
1. 100050,首都医科大学附属北京天坛医院神经病学中心国家神经系统疾病临床医学研究中心
- Keywords:
Stroke;
Ischemic attack;
transient;
Antiplatelet therapy;
Hemorrhage;
Lipid
- From:
Chinese Journal of Internal Medicine
2018;57(10):723-730
- CountryChina
- Language:Chinese
-
Abstract:
Objective Abnormalities of lipid profile were considered as risk factors of hemorrhage after ischemic stroke. We aimed to determine the relationship between lipid levels and bleeding in minor stroke or transient ischemic attack (TIA) patients receiving antiplatelet therapy. Methods Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride were tested in a subgroup of 3044 consecutive patients from Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial. Patients were randomized to clopidogrel plus aspirin group or single aspirin group. The primary endpoint was any bleeding within 90 days. The secondary endpoint was severe bleeding according to the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) definition. Cox proportional hazards models were used to assess the associations of lipid levels and outcomes. Results A total of 59 (1.9％) bleeding events occurred at 90 days. High-density lipoprotein cholesterol (adjusted HR=2.16; 95％CI 1.17-4.00, P=0.014) and age (adjusted HR=1.04;95％CI 1.01-1.06, P=0.006) were significantly associated with any bleeding. High-density lipoprotein cholesterol was also associated with severe bleeding (adjusted HR=3.05;95％CI 1.39-6.68, per 1 mmol/L increase). No correlations between outcomes and levels of total cholesterol, low-density lipoprotein cholesterol and triglyceride were found. There was no interaction of any lipid component level with randomized antiplatelet therapy. Conclusions Elevated high-density lipoprotein cholesterol is independently associated with any bleeding and severe bleeding in the patients with acute minor stroke or high-risk TIA on antiplatelet therapy.
