The diagnostic value of copeptin in the cardiorenal syndrome rats and the association with heart and kidney impairment
10.3760/cma.j.issn.0578-1426.2018.07.010
- VernacularTitle:和肽素对心肾综合征大鼠的诊断价值及与心肾损害的关系
- Author:
Xiaosheng SHENG
1
;
Mingxing DING
;
Fangming GUO
;
Zhangping YU
;
Xian HUA
;
Li LIN
Author Information
1. 321000,浙江省金华市人民医院心内科
- Keywords:
Cardiorenal syndrome;
Copeptin
- From:
Chinese Journal of Internal Medicine
2018;57(7):518-521
- CountryChina
- Language:Chinese
-
Abstract:
To explore the diagnostic value of copeptin (CPP) in cardiorenal syndrome (CRS) in rats and the association between CPP and impairment of heart and kidney, 60 male SD rats were randomly divided into blank control group (CK group), kidney failure group (SNX group), heart failure group (MI group), and CRS group. Heart and kidney function and their histology changes in rats from each group were detected. The correlation between serum CPP and heart and kidney function indexes was performed with Pearson correlation analysis. The HE staining of heart and kidney showed that the tissue lesion was more severe in CRS group than in SNX group and MI group. There was a significant positive correlation between serum CPP and brain natriuretic peptide (BNP) (r=0.638, P<0.05). No correlation was observed between serum CPP and cardiac function index (left ventricular systolic pressure, left ventricular diastolic pressure, left ventricular end-diastolic pressure) or renal function index (serum creatinine, urine creatinine, blood urea nitrogen) (r=0.512, 0.189, -0.063, 0.207, 0.290, 0.595, respectively, all P>0.05). The CPP level is associated with the degree of heart and kidney damage in CRS rats.
