A clinical study of mental stress-induced myocardial ischemia in patients with stable coronary artery disease and depression/anxiety
10.3760/cma.j.issn.0578-1426.2018.07.005
- VernacularTitle:稳定性冠心病伴抑郁焦虑患者的精神压力诱发心肌缺血临床研究
- Author:
Lijun ZHANG
1
;
Dongfang HE
;
Ya YANG
;
Lihong PU
;
Liyuan XU
;
Yuxin ZHOU
;
Meiyan LIU
Author Information
1. 100029,首都医科大学附属北京安贞医院心脏中心
- Keywords:
Coronary artery disease;
Mental stress;
Depression;
Anxiety
- From:
Chinese Journal of Internal Medicine
2018;57(7):494-499
- CountryChina
- Language:Chinese
-
Abstract:
Objectives Exploring the association between depression/anxiety and mental stress-induced myocardial ischemia (MSIMI) in patients with stable coronary artery disease (CAD). Methods A total of 178 subjects was enrolled according to the inclusion and exclusion criterion with 88 men and 90 women at age of (54±12)years. The subjects were divided into four groups including CAD with depression/anxiety, CAD without depression/anxiety, depression/anxiety without CAD, and control group based on the state of coronary artery, the scores of Patient Health Questionnaire 9-item (PHQ-9) and Generalized Anxiety Disorder 7-item(GAD-7). MSIMI was diagnosed by echocardiography. Data were analyzed by SPSS19.0. Results The incidence of MSIMI in all CAD patients was 17.24%. Within each group, 35.00% patients were MSIMI in CAD with depression/anxiety, 2.13% were in CAD without depression/anxiety, 14.29% were in depression/anxiety without CAD, and 2.38% were in control group. The risks of MSIMI in depression/anxiety without CAD and with CAD groups were 6.83 (P>0.05) and 22.08 times (P<0.05) higher than that in control group, respectively. Logistic regression showed that a 1-point increment in the GAD-7 score, but not PHQ-9 score [ OR=0.95, 95% CI (0.77-1.17), P=0.63], was associated with 1.22-fold increase in the likehood of MSIMI [95% CI (1.07-1.38), P=0.00]. Conclusions The MSIMI rate is much higher in patients with CAD comorbid depression/ anxiety compared with CAD without depression/anxiety. Anxiety, but not depression, is an independent risk factor of MSIMI in CAD patients.
