A clinical analysis of hepatic veno-occlusive disease after hematopoietic stem cell transplantation

VernacularTitle:造血干细胞移植后肝静脉闭塞病的临床分析
Author: Chunjie QIN ¹ ; Lianjin LIU ; Zhongming ZHANG ; Lin LUO ; Yongrong LAI ; Qiaochuan LI
Author Information

1. 广西柳州市工人医院血液内科
Keywords: Hematopoietic stem cell transplantation; Hepatic veno-occlusive disease; Risk factors
From: Chinese Journal of Internal Medicine 2018;57(7):483-486
CountryChina
Language:Chinese
Abstract: Objective To analyze the outcome and the prognostic factors of hepatic veno-occlusive disease (HVOD) after hematopoietic stem cell transplantation (HSCT). Methods A total of 797 patients receiving HSCT were analyzed retrospectively. The prophylaxis regimen of HVOD in the First Affiliated Hospital of Guangxi Medical University consisted of low molecular weight heparin and lipoprostaglandin E1 (PGE1). Results Fifty-nine patients (7.4%) developed HVOD at 3-49 days after HSCT (median 12 days). Age younger than 15 years at transplant( HR=6.47, P<0.001), busulphan conditioning ( HR=6.40, P<0.001), thalassemia major ( HR=6.35,P<0.001), allogeneic transplantation ( HR=7.74, P=0.005) were univariate risk factors for HVOD. Multivariate analyses suggested that thalassemia major and busulphan conditioning were independently correlated with the development of HVOD. Conclusion Thalassemia major and busulphan conditioning are independent risk factors for HVOD after HSCT.