The expression and significance of CD276 and CD133 in colorectal cancer and precancerous lesions
10.3760/cma.j.issn.0578-1426.2018.06.011
- VernacularTitle:CD276和CD133在结直肠癌及癌前病变中的表达及意义
- Author:
Gaofeng LU
1
;
Lina HUANG
;
Jingli REN
;
Guiming HU
;
Ziheng ZHENG
;
Jiaxun WU
;
Yipeng ZHU
;
Fuai TANG
Author Information
1. 450014,郑州大学第二附属医院消化内科
- Keywords:
Antigens,CD276;
Antigens,CD133;
Colorectal neoplasms;
Adenoma;
Prognosis
- From:
Chinese Journal of Internal Medicine
2018;57(6):450-453
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the significance of CD276 and CD133 in the development and progression of colorectal cancer (CRC),the expression of CD276 and CD133 was detected by immunohistochemistry in CRC and precancerous lesions.The results showed that the intensity of CD276 and CD133 in CRC samples was higher than that in adenoma group and non-adenoma group.CD276 and CD133 single and double positive expression were significantly correlated with CRC lymph node metastasis,distant metastasis and survival.CD276 and CD133 are significantly correlated to the development and progression of CRC and associated with poor prognosis.
