Clinical characteristics of central diabetes insipidus: a retrospective analysis of 230 cases
10.3760/cma.j.issn.0578-1426.2018.03.010
- VernacularTitle:230例中枢性尿崩症患者病因分布及临床特点分析
- Author:
Jiping ZHANG
1
,
2
;
Qinghua GUO
;
Yiming MU
;
Zhaohui LYU
;
Weijun GU
;
Guoqing YANG
;
Jin DU
;
Jianming BA
;
Juming LU
Author Information
1. 100853北京,解放军总医院内分泌科
2. 江苏省连云港市第一人民医院内分泌科,222000
- Keywords:
Diabetes insipidus,central;
Etiology;
Pituitary gland,anterior
- From:
Chinese Journal of Internal Medicine
2018;57(3):201-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical characteristics and etiologies of central diabetes insipidus (CDI).Methods The clinical data of 230 patients with CDI in the Department of Endocrinology of Chinese PLA General Hospital from 2008 June to 2014 December were collected and analyzed retrospectively.Results The three most common causes of CDI were idiopathic CDI,lymphocytic hypophysitis and intracranial germ cell tumors.Among all the CDI,the idiopathic CDI accounted for 37.48％.There were significant differences in age onset and gender distribution among the different causes of CDI.The patients with intracranial germ cell tumors [age of onset(19.2± 10.2) years] were younger than the other types of CDI.Germ cell tumors patients were more common in male,and lymphocytic hypophysitis patients were more common in female.The most frequent abnormality of anterior pituitary in patients with CDI was growth hormone deficiency,followed by hypogonadism,adrenal insufficiency and hypothyroidism.The dysfunction of thyroid axis and adrenal axis in patients with germ cell tumor was more common than those in patients with idiopathic and lymphocytic hypophysitis.Conclusions The most common causes of central diabetes insipidus were idiopathic CDI,lymphocytic hypophysitis and intracranial germ cell tumors.There were differences in age of onset,gender distribution and abnormal production of anterior pituitary hormones among all causes of CDI patients.
