An analysis of clinical characteristic and related risk factors in 208 cirrhotic patients complicated with infections
10.3760/cma.j.issn.0578-1426.2018.02.007
- VernacularTitle:208例肝硬化合并感染患者的临床特点及相关因素分析
- Author:
Guanhua ZHANG
1
;
Min WANG
;
Lan WANG
;
Xiaoming WANG
;
Yu WANG
;
Xiaojuan OU
;
Jidong JIA
Author Information
1. 100050,首都医科大学附属北京友谊医院肝病中心 北京市肝硬化转化医学重点实验室
- Keywords:
Liver cirrhosis;
Infection
- From:
Chinese Journal of Internal Medicine
2018;57(2):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features and risk factors of cirrhotic patients complicated with infections. Methods The clinical and laboratory characteristics of cirrhotic patients complicated with infections hospitalized from April 2014 to June 2017 were retrospectively analyzed. Relevant risk factors for infection and mortality were explored. Results The overall incidence of infections was 17.6％ in 1670 hospitalized cirrhotic patients. Among the recruited 208 patients in this study, alcoholic, viral hepatitis B or C and autoimmune liver diseases accounted for 29.8％ (62/208), 26.0％ (54/208), and 22.1％ (46/208), respectively. The most common infection site was respiratory tract (70.2％ ), followed by urinary tract, intestinal and intra-abdomen. Forty-six pathogens were isolated from 32 patients, including 22 (47.8％ ) Gram negative bacteria, 16 (34.8％ ) Gram positive bacteria and 2(4.3％ ) mycobacterium tuberculosis, 5 (10.9％) fungi and 1 (2.2％) mycoplasma. The mortality in patients with nosocomial infections (16.7％,7/42) was higher than that in patients with community-acquired infections (6.0％,10/166, P=0.025). All 17 deaths occurred in decompensated cirrhosis. Multivariate analysis demonstrated that hepatic encephalopathy and prothrombin time were independent risk factors of mortality. Conclusions Patients with decompensated cirrhosis are more susceptible to infections. Hepatic encephalopathy and prothrombin time are independent risk factors for death.
