Approach to the patient with POEMS syndrome first manifested as Addison's disease
10.3760/cma.j.issn.1000-6699.2018.11.012
- VernacularTitle:以Addison病为首发表现的POEMS综合征的临诊应对
- Author:
Lin LU
1
;
Linxia WANG
;
Xiaoping XING
;
Congli ZHANG
;
Jian LI
Author Information
1. 100730 中国医学科学院北京协和医学院,北京协和医院内分泌科,国家卫生健康委员会内分泌重点实验室
- Keywords:
Addison's disease;
POEMS syndrome;
Polyendocrinopathies;
Autoimmune
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(11):955-959
- CountryChina
- Language:Chinese
-
Abstract:
A middle aged male presented with darkened skin and edema of lower extremities was reported. He was diagnosed as primary adrenocortical insufficiency ( Addison' s disease ) accompanied with hypergonadotropic hypogonadism, hypoparathyroidism, and subclinical hypothyroidism after endocrinological workup. In addition, the patient also had thickened skin, hirsutism, and polyserositis. The diagnosis of POEMS syndrome was confirmed by elevated M protein and VEGF level. The image of CT showed normal adrenals. Besides the autoimmune polyglandular syndrome ( APS), the possibility of POEMS syndrome in an adult patient with multiple endocrine dysfunction should be considered.
