Emodin alleviated kidney damage in high fat diet induced obese mice
10.3760/cma.j.issn.1000-6699.2018.11.010
- VernacularTitle:大黄素对高脂饮食诱导的肥胖小鼠肾脏损害的保护作用
- Author:
Yao SUN
1
;
Yali YU
;
Jiang LI
;
Haiou ZHANG
Author Information
1. 泰康仙林鼓楼医院药剂科
- Keywords:
Obesity;
Emodin;
Kidney damage;
Insulin resistance;
Collagen Ⅳ
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(11):946-950
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protective effect of emodin on kidney damage in high-fat diet-induced obese mice. Methods Male C57bl/ 6 mice were divided into groups according to diet and treatment. Collagen Ⅳ(Col4), phosphatidylinositide 3-kinase(PI3K), phosphorylated phosphoinositol 3-kinase(p-PI3K), protein kinase (Akt), and phosphorylated protein kinase(p-Akt) were measured by Western blotting method. Results Col4 was increased, while p-PI3K and p-Akt were decreased in kidney tissue in high-fat diet-induced obese mice. However, there was lower level of Col4, but higher levels of p-PI3K and p-Akt in kidneys. Conclusion Kidney damage of high-fat diet-induced obese mice seems to be alleviated by emodin via improving insulin sensitivity.
