A retrospective study of 14 cases of glucagonoma with literature review
10.3760/cma.j.issn.1000-6699.2018.11.003
- VernacularTitle:胰升糖素瘤14例病例总结并文献复习
- Author:
Wei LIU
1
;
Xiaoping XING
;
Feng GU
;
Lingling XU
;
Kai FENG
;
Xiaofeng CHAI
;
Yong FU
;
Ou WANG
;
Miao YU
Author Information
1. 100730 中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫健委内分泌重点实验室
- Keywords:
Glucagonoma;
Necrolytic migratory erythema;
Diabetes mellitus;
Neuroendocrine tumor
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(11):909-914
- CountryChina
- Language:Chinese
-
Abstract:
Objective To improve the clinical understanding of glucagonoma. Methods A total of 14 cases of glucagonoma were admitted to our hospital, and the clinical features of these cases were retrospectively analyzed. Results (1) The female/ male case ratio was 1 : 1. (2) The median age of onset was 47 years (range 33-61), while the median age at diagnosis was 50 years (range 33-64). (3) The most common initial presentation was necrolytic migratory erythema (7/ 14, 50％). (4) Hyperglycemia was the most common presentation at the time of diagnosis (14/ 14, 100％), followed by necrolytic migratory erythema (13/ 14, 92.9％). (5) The misdiagnosis rate before admission to our hospital was as high as 85.7％ (12/ 14), and the most common misdiagnosis was eczema (7/ 12, 58.3％). (6) The median time from onset of probable symptoms to diagnosis was 4 years. (7) The median plasma glucagon level at diagnosis was 798 pg/ ml (range 200-2853). (8) The median length of the longest tumor diameter of the pancreatic tumors at diagnosis was 4. 0cm ( range 2. 2-8. 0). ( 9) 57. 1％ of primary pancreatic glucagonomas localized in the tail of the pancreas. (10) 57.1％ of patients (8/ 14) had metastases at the time of diagnosis. Conclusions (1)Necrolytic migratory erythema is a relatively sensitive and specific symptom for diagnosis of glucagonoma. (2) The diagnosis for glucagonoma was often delayed, and misdiagnosis was common. ( 3) Most glucagonoma patients had metastases at the time of diagnosis.
