Research progress on the genes related to androgens in polycystic ovary syndrome

VernacularTitle:多囊卵巢综合征与雄激素作用有关易感基因的研究进展
Author: Tianyue ZHANG ¹ ; Yifei ZHANG ; Guang NING
Author Information

1. 200025 上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所
Keywords: Polycystic ovary syndrome; Hyperandrogenism; Genome wide association study; Epigenetics
From: Chinese Journal of Endocrinology and Metabolism 2018;34(10):895-898
CountryChina
Language:Chinese
Abstract: Polycystic ovary syndrome( PCOS) is one of the most common endocrine disorders in women of reproductive age, resulting in several health complications such as menstrual dysfunction, infertility, hirsutism, acne, obesity, and metabolic syndrome. PCOS is recognized to be a complex polygene disease. Although the cause of PCOS has not been fully clarified, hyperandrogenism is one of the key pathogenesises of PCOS. In this article, we reviewed the effects of genes related to androgen biosynthesis,metabolism,reserve,action and regulation on the pathogenesis of PCOS based on the research progress in the candidate gene studies, genome wide association studies, as well as its epigenetics.