Research advances in functional regulation of islet α cells

VernacularTitle:胰岛α细胞的功能调控研究进展
Author: Jia SONG ¹ ; Xinguo HOU ; Chen CUI ; Li CHEN
Author Information

1. 山东大学齐鲁医院内分泌科、山东大学内分泌代谢病研究所、山东省医药卫生内分泌与代谢病重点实验室
Keywords: Pancreaticαcells; Glucagon; Islet function
From: Chinese Journal of Endocrinology and Metabolism 2018;34(10):876-881
CountryChina
Language:Chinese
Abstract: Dysfuntion ofα cells plays a critical role in the pathogenesis of diabetes. Its own transcription factors, posttranscriptional modification, transporters related to secretion and paracrine signals fromβ and δ cells, inflammatory factors, and carbohydrates, lipids, amino acids, all influenceαcell function. We summaried the various factors involved in the regulation ofαcell function as well as recent related advances on their molecular mechanisms.