Association of age at menarche with the risks of diabetes mellitus and metabolic syndrome in adulthood in Shanghai Jiading community postmenopausal women
10.3760/cma.j.issn.1000-6699.2018.10.002
- VernacularTitle:上海嘉定社区绝经后女性初潮年龄与成年后糖尿病及代谢综合征患病风险的相关性研究
- Author:
Chunyan HU
1
;
Lin LIN
;
Rui DU
;
Xueyan WU
;
Yuhong CHEN
;
Jieli LU
;
Yufang BI
;
Weiqing WANG
;
Guang NING
Author Information
1. 200025 上海交通大学医学院附属瑞金医院 内分泌代谢病科,上海市内分泌代谢病研究所,上海市内分泌代谢病临床医学中心
- Keywords:
Age at menarche;
Menopausal status;
Metabolic syndrome;
Diabetes mellitus;
Body mass index
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(10):814-820
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of age at menarche with the risks of diabetes and metabolic syndrome ( MS) in adulthood in Shanghai community postmenopausal women. Methods A total of 10375 residents over 40 years in Jiading, Shanghai were identified by a cluster sampling method. After taking standardized questionnaire surveys, physical examinations, and biochemical parameters testing, we gathered their lifestyle and medicine information. A total of 4723 postmenopausal women were enrolled in the study. The population was divided into three groups according to age at menarche, and their risks of MS and diabetes in various groups were compared. Results After multivariate adjustment, postmenopausal women with a menarche age<15 years had a 29％increased risk of diabetes(95％CI 1.03-1.61) and a 45％ increased risk of MS(95％ CI 1.20-1.76) in adulthood, compared with those with menarcheal age at 15-18 years. Among the five components of MS, earlier age of menarche was associated with higher risks of hypertriglyceridemia, low high density lipoprotein-cholesterol, and central obesity. Conclusions In Shanghai Jiading community postmenopausal women, age at menarche is associated with the risk of diabetes and MS, independent of the body mass index in adulthood.
