Association of serum alanine aminotransferase with the risk of cardiovascular disease in middle-aged and elderly Chinese
10.3760/cma.j.issn.1000-6699.2018.09.006
- VernacularTitle:中老年人群血清谷丙转氨酶水平与心血管疾病风险的相关性研究
- Author:
Lina MA
1
;
Di CHENG
;
Rui DU
;
Xueyan WU
;
Yu XU
;
Min XU
;
Yuhong CHEN
;
Yufang BI
;
Weiqing WANG
;
Jieli LU
Author Information
1. 200025 上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病研究所,上海市内分泌代谢病临床医学中心
- Keywords:
Alanine aminotransferase;
Cardiovascular disease;
Middle-aged and elderly people;
ASCVD risk score
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(9):746-754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between levels of serum alanine aminotransferase (ALT) and the risks of cardiovascular disease in Chinese. Methods A survey of 10 375 subjects aged 40 or older in Jiading District of Shanghai was performed using cluster sampling. All the subjects were recruited to undergo questionnaire interview, anthropometric measurements, and fasting blood sampling. A total of 8 877 participants were included in the final analyses, including 5 664 females and 3 213 males. The mean age of individuals was ( 58.68 ± 9.22)yearsinmenand(57.65±8.93)yearsinwomen(P＜0.01).10-yearriskforafirsthardatherosclerotic cardiovascular diseases (ASCVD) event was calculated. Results Increased ALT levels were associated with more unfavorable cardiovascular risk profiles and 10-year risk for ASCVD. Increased ALT levels were associated with the prevalence of diabetes mellitus in female participants, while in male participants the prevalence of diabetes mellitus appeared as a U-distribution. The prevalence of hypertension and hyperlipidemia were 66.04%, 52.74%and 64.49%, 47.63% respectively. Increased serum ALT was associated with higher prevalence of 10-year risk for ASCVD. As compared with participants in the first ALT quartile, the risks of 10-year risk for ASCVD were increased by 148%(OR＝2.48, 95%CI 1.78-3.45) and 139%(OR＝2.39, 95%CI 1.78-3.19), respectively in male and female participants. As compared with participants in the first ALT quartile, higher prevalence of 10-year risk for ASCVD were increased by 96%(OR＝1.96, 95%CI 1.30-2.95), while there was no significantly statistical difference in men. Conclusion A high-normal serum ALT level was significantly associated with an increased risk of the cardiovascular disease in middle-aged and elderly Chinese.
