Correlation of hypoxia inducible factors, vascular endothelial growth factor receptor 2, and microvessel density expressions with angiogenesis in adrenocortical tumours
10.3760/cma.j.issn.1000-6699.2018.09.002
- VernacularTitle:缺氧诱导因子、血管内皮生长因子受体2及微血管密度在肾上腺皮质肿瘤中的表达及意义
- Author:
Ran ZHUO
1
;
Wenming MA
;
Xiaoqun YANG
;
Zhaofu WANG
;
Tingwei SU
;
Fukang SUN
;
Weiqing WANG
Author Information
1. 200025,上海交通大学医学院附属瑞金医院泌尿外科
- Keywords:
Adrenal tumour;
Hypoxia inducible factor-2α;
Hypoxia inducible factor-1α;
Vascular endothelial growth factor receptor 2;
Microvessel density;
Immunohistochemistry
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(9):721-725
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expressions of hypoxia inducible factor ( HIF), vascular endothelial growth factor receptor 2 ( VEGFR 2), and microvessel density ( MVD) in adrenocortical adenoma ( ACA) and adrenocortical carcinoma ( ACC), in order to discuss their potential role in the development of adrenal tumours. Methods Fifty-five adrenal tumour specimens resected in the hospital with complete clinical data (including 30 ACA cases and 25 ACC cases) were examined by immunohistochemistry for the expressions of HIF-2α, HIF-1α, VEGFR 2, and MVD. Results VEGFR 2 and MVD up-regulated were found in the ACC group (P＜0.05). The expression of HIF-2α and HIF-1α correlated with VEGFR 2 (P＜0.05). The expressions of VEGFR 2 and MVD were related to some clinicopathological features ( P＜0. 05 ). Additionally, tumour size, expression of VEGFR 2 and MVD were independently associated with ACC (P＜0.05). Conclusions The high expression of HIF-2α, VEGFR 2, and MVD in adrenal tumours suggested their roles in tumour angiogenesis, which indicated that anti-angiogenesis therapies deserve intensive studies for malignant adrenocortical tumours.
