Role of melanocortin receptor-4 in energy regulation and obesity

VernacularTitle:黑皮质素受体4在能量调节及肥胖中的作用
Author: Jiao LIU ¹ ; Lu ZHENG ; Di ZHAO ; Guijun QIN ; Jing WU ; Yanhui BAI ; Haohao ZHANG
Author Information

1. 450052,郑州大学第一附属医院内分泌科
Keywords: Melanocortin receptor-4; Melanocortin system; Energy regulation; Obesity
From: Chinese Journal of Endocrinology and Metabolism 2018;34(8):699-702
CountryChina
Language:Chinese
Abstract: As a pandemic metabolic disease, obesity has become a worldwide problem, which endangering human health. The change in body weight reflects the energy imbalance. And the homeostasis regulation of the central and peripheral melanocortin system may maintain the energy balance and then affect the body weight. Recent studies have found that melanocortin receptor-4 ( MC4R) plays an important role in energy homeostasis and body weight changes, but its specific mechanism needs further elucidation. In this paper, we reviewed the research progress of MC4R in body weight and energy regulation, so as to provide a theoretical basis for further exploring the potential role of MC4R in improving energy metabolism imbalance and obesity.