Association of serum ghrelin level with cognition, hippocampal volume, and proton magnetic resonance spectrum in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2018.08.005
- VernacularTitle:血清胃促生长素水平与2型糖尿病患者认知功能、海马体积及氢质子磁共振波谱变化之间的相关性研究
- Author:
Yukai LI
1
;
Zhizhou XIAO
;
Liya LIAO
;
Jie FU
;
Hongyan DENG
Author Information
1. 4300331,武汉市第四医院(华中科技大学同济医学院附属普爱医院)内分泌科
- Keywords:
Ghrelin;
Diabetes mellitus,type 2;
Cognition;
Hippocampal volume;
Proton magnetic resonance spectrum
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(8):649-654
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of serum ghrelin level with cognition, hippocampal volume, and proton magnetic resonance spectrum ( [ 1 H ]-MRS ) in patients with type 2 diabetes mellitus ( T2DM) . Methods The T2DM patients cared at the Wuhan Fourth Hospital were recruited. Data on demographic characteristics and clinical parameters were collected. Ghrelin was measured by ELISA assay. Cognitive performance was assessed by the Montreal Cognitive Assessment ( MoCA ) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The changes of metabolites in hippocampus were detected by [1 H]-MRS, including N-acetyl asparate ( NAA) , choline ( Cho) , myo-inositol ( MI) , creatine ( Cr) . All patients were divided into 2 groups[cognitive impairment (CI) and non-cognitive impairment (NCI) groups] by MoCA. Results (1) Compared with patients in NCI group, the serum ghrelin level, bilateral hippocampal volume, and NAA/Cr ratio of [1H]-MRS metabolites in CI group were decreased, but MI/Cr and Cho/Cr ratios were increased(all P<0.05). (2) Serum ghrelin was positively correlated with a variety of RBANS scores ( including immediate memory, attention, delayed memory, and total scores) , bilateral hippocampal volume, and NAA/Cr ratio of [ 1 H]-MRS metabolites in T2DM patients, but it was negatively correlated with MI/Cr ratio and Cho/Cr ratio ( all P<0. 05 ) . ( 3 ) Logistic regression analysis showed that ghrelin was a protective factor of cognition in T2DM patients. Conclusions T2DM patients with cognitive impairment had lower levels of ghrelin, and serum ghrelin was postively correlated with their cognitive performance, hippocampal volume, and [1 H]-MRS metabolites, suggesting that serum ghrelin may be involved in the occurrence and development of cognitive dysfunction in patients with T2DM.
