Evaluation of β-cell mass in type 2 diabetic patients with 18F-FP-(+)-DTBZ,a vesicular monoamine transporter type 2 molecular probe
10.3760/cma.j.issn.1000-6699.2018.08.003
- VernacularTitle:2型囊泡单胺转运体分子探针[18F]-FP-(+)-DTBZ对2型糖尿病患者胰岛β细胞总量的评价
- Author:
Donglang JIANG
1
;
Yanyan KONG
;
Xiuhong LU
;
Ming LI
;
Weiyan ZHOU
;
Fengchun HUA
;
Fang XIE
;
Yihui GUAN
Author Information
1. 复旦大学附属华山医院PET中心
- Keywords:
Diabetes mellitus;
Positron emission tomography;
β-cell mass;
VMAT2
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(8):638-642
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to evaluate theβ-cell mass ( BCM) in patients with type 2 diabetes mellitus( T2D) by PET/CT using [ 18 F]-FP-(+)-DTBZ, which is a vesicular monoamine transporter type 2 molecular probe. The feasibility of pancreatic head, body and tail as the target area was investigated for evaluation of the BCM in T2D. Methods 15 subjects ( 8 with T2D, and 7 as control) were involved in this study with 20 min static PET imaging at 40 min post injection of [ 18 F]-FP-(+)-DTBZ. The volume of interest ( VOIs) of pancreatic head, body and tail were drawn and quantitatively assessed. Spleens were collected as reference tissue for SUVR calculation. Results SUVR in the pancreatic head ( SUVR=1.72 ± 0.47) and pancreatic body, tail ( SUVR=1.85 ± 0.41) in T2D group was no significant difference, and no significant difference was observed in the pancreatic head (SUVR=2.54±0.57) and pancreatic body, tail(SUVR=2.73±0.41) in control group as well. In T2D group, a significant decreased SUVR was found in pancreatic head (P=0.0088) and pancreatic body and tail (P=0.0012) compared with controls. Conclusion The VMAT2 molecular probe [ 18 F]-FP-(+)-DTBZ can be used to evaluate BCM in patients with T2D.
