Clinical Observations on Tuberculous Meningitis in Childhood.
- Author:
Seung Joon PARK
1
;
Young Soo YOON
;
Yon Nam KIM
;
Ki Bok KIM
Author Information
1. Department of Pediatrics, Kwanju Christian Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Tuberculous Meningitis in Childhood;
Clinical Observations
- MeSH:
Fever;
Gwangju;
Headache;
Humans;
Incidence;
Infant;
Leukocytes;
Lymphocytes;
Mortality;
Neck;
Neurologic Manifestations;
Parents;
Pediatrics;
Seasons;
Seizures;
Thorax;
Tuberculin Test;
Tuberculosis;
Tuberculosis, Meningeal*;
Tuberculosis, Miliary;
Vaccination;
Vomiting
- From:Journal of the Korean Pediatric Society
1981;24(8):723-734
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A clinical study was carried out on patients with tuberculous meningitis who were admitted to the Department of Pediatrics, Kwangju Christian Hospital during a 9 year period from January, 1971 to December, 1979. The following results were obtained. 1) About 3/4 of all cases were under the age of 6, the majority being between the age of one and three. The male-to-female ratio was 1.3:1. 2) Seasonal incidence was in the order of spring, summer, winter and autumn, but no sign ificant differences were noted. 3) A family history of tuberculosis was found in 41.5%, usually in one of the parents. 4) A history of B.C.G. vaccination was found in 16.7% of tuberculous meningitis cases. The tuberculin test was positive in 28.9%. 5) The most frequent symptoms on admission were vomiting, fever, convulsion and headache, in that order. 6) The major neurologic findings were unconsciousness(34.0%), neck stiffness(76.4%), and positive Kernig's sign(63.2%). 7) Leukocytes in the C.S.F. on admission were generally elevated, but below the range of 500/mm3 in 74.5% of cases, and the mean count was 278.7/mm3 with 66.7% lymphocytes. Mean protein level in the C.S.F. was 162.5mg/dl, and 94.3% of all cases were over 50mg/dl. Sugar in the C.S.F. was definitely reduced to less than 120 mEq/L in 78.3%, with the mean level being 112.8mEq/L. 8) Chest X-ray revealed tuberculous lesions in 69.8% and miliary tuberculosis was found in 36.8% of cases. 9) The highest mortality was seen in young infants. Among 26 patients of clinical stage I on admission, 21(80.3%) recovered, and 35(79.5%) of 44 patients of stage II recovered, whereas only 13(36.1%) out of 36 patients of stage III were cured. Over-all mortality rate was 5.7% of those followed.
