Research advances on the TCA cycle in pheochromocytoma and paraganglioma
10.3760/cma.j.issn.1000-6699.2018.05.013
- VernacularTitle:三羧酸循环在嗜铬细胞瘤和副神经节瘤中的相关研究进展
- Author:
Jiying QI
1
;
Tingwei SU
Author Information
1. 200025 上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所
- Keywords:
Pheochromocytoma and paraganglioma;
Susceptibility genes;
Pseudohypoxia
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(5):423-425
- CountryChina
- Language:Chinese
-
Abstract:
In pheochromocytoma and paraganglioma (PPGL), mutations in the TCA cycle related genes may lead to the disturbance of the TCA cycle's intermediate metabolite levels, then cause pseudohypoxia by abnormal hypoxia-inducible factor ( HIF) activation, it also may lead to epigenetic changes, impede cell differentiation and apoptosis, and finally promote the occurrence and development of PPGL. This review focus on the research advances on the TCA cycle in the pathogenesis of PPGL, as well as the application of relevant detection methods.
