Islet β-cell function in patients with gout and hyperuricemia accompanied by increased 1h postload plasma glucose
10.3760/cma.j.issn.1000-6699.2018.04.006
- VernacularTitle:痛风及高尿酸血症患者1h血糖增高时胰岛β细胞功能状态
- Author:
Jie ZHANG
1
;
Guoran XIE
;
Xinghuan LIANG
;
Jia ZHOU
;
Jing XIAN
;
Song HUANG
;
Li LI
;
Yingfen QIN
Author Information
1. 广西医科大学第一附属医院内分泌科
- Keywords:
Gout;
Hyperuricemia;
β-cell function
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
All of 143 patients with gout or hyperuricemia were divided into type 2 diabetes(n=43), impaired glucose regulation(n=45),and normal glucose tolerance(n=55)groups. Moreover,a cut point of 8.6 mmol/L in one hour postload plasma glucose(1hPG)of oral glucose tolerance test was used to sub-divide the normal glucose tolerance group into 1hPG≥8.6 mmol/L(n=30)and 1hPG<8.6 mmol/L(n=25)groups. The first-and second-phase insulin secretion indexes were compared among four groups. The results showed that there was no statistical difference in the second-phase insulin secretion index among impaired glucose regulation,1hPG≥8.6 mmol/L,and 1hPG<8.6 mmol/L groups(P>0.05). The first-phase insulin secretion index revealed no significant difference between impaired glucose regulation and 1hPG≥8.6 mmol/L groups(P>0.05),but obviously decreased in these two groups compared with 1hPG<8.6 mmol/L group(P<0.05). The modified β cell function indexes were gradually decreased in 1hPG<8.6 mmol/L,1hPG≥8.6 mmol/L, and impaired glucose regulation groups(P<0.05). These results suggest that when 1hPG of the patients with gout and hyperuricemia is over 8.6 mmol/L,the first-phase insulin secretion will be impaired.
