Independent and joint effect of brachial-ankle pulse wave velocity and body mass index level on incident diabetes with hypertension
10.3760/cma.j.issn.1000-6699.2018.04.004
- VernacularTitle:肱踝脉搏波速度和体重指数对糖尿病合并高血压发生风险的独立和联合作用
- Author:
Jie WANG
1
;
Yu PEI
;
Kang CHEN
;
Wenhua YAN
;
Anping WANG
;
Yijun LI
;
Weijun GU
;
Haibing WANG
;
Ping AN
;
Xinye JIN
;
Guang NING
;
Yiming MU
Author Information
1. 解放军总医院内分泌科
- Keywords:
Diabetes with hypertension;
Brachial-ankle pulse wave velocity;
Body mass index
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(4):287-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether brachial-ankle pulse wave velocity(baPWV),independently and jointly with the level of body mass index(BMI),affect the risk of incident diabetes with hypertension. Methods The effects of baPWV and BMI level on incident diabetes with hypertension were evaluated using Kaplan-Meier curves (log-rank test) and multi logistical regression models after adjustment for various confounding factors. Results A total of 2 222 participants were recruited in this study. Higher baPWV (Q4) was associated with a greater risk of incident diabetes with hypertension simultaneously compared with baPWV in the lower quartiles(Q1-Q3),with HR 4.16(95% CI 2.14,8.09)in the crude model,2.52(95% CI 1.10,5.78) in modelI,and 2.45(95% CI 1.05, 5.70)in modelⅡ.The highest risk of diabetes with hypertension simultaneously was in the group with high baPWV and BMI≥25 kg/m2,with HR 11.50(95% CI 4.5,29.9)in the crude model,4.20(95% CI 1.4,13.1)in modelI,and 4.30(95% CI 1.4,13.3) in modelⅡ. Conclusions The joint effect of baPWV and BMI level on incident diabetes with hypertension simultaneously is a better predictor than their independent effect. The risk of incident diabetes with hypertension markedly increases in the subjects with BMI≥25 kg/m2and higher baPWV.
