Association of serum Fetuin-B with metabolic syndrome in obese Chinese adults
10.3760/cma.j.issn.1000-6699.2018.03.006
- VernacularTitle:肥胖成年人血清胎球蛋白B水平与代谢综合征关系研究
- Author:
Yongwen LIU
1
;
Dongmei WANG
;
Zhibin LI
;
Mingzhu LIN
;
Changqin LIU
;
Zheng CHEN
;
Xiulin SHI
;
Shuyu YANG
;
Xuejun LI
Author Information
1. 361003,厦门大学附属第一医院内分泌糖尿病科
- Keywords:
Fetuin-B;
Non-alcoholic fatty liver disease;
Metabolic syndrome;
Insulin resistance;
Cross-sectional study
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(3):217-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the independent association of serum Fetuin-B with metabolic syndrome in obese Chinese adults.Methods Cross-sectional data on socio-demographic,lifestyle,clinical characteristics, and serum Fetuin-B were collected for 1 318 Chinese adults with central obesity.Associations of serum Fetuin-B with metabolic syndrome and insulin resistance were analyzed using multivariable Logistic regression analysis.Results A total of 820(62.2%)individuals were identified as metabolic syndrome.Subjects with metabolic syndrome showed significantly increased levels of serum Fetuin-B than those with non-metabolic syndrome[(4.18 ±1.39 vs 4.02 ± 1.35)μg/ml,P=0.043].Increased serum Fetuin-B were significantly associated with increased fasting plasma glucose and insulin levels, as well as prevalences of non-alcoholic fatty liver disease(NAFLD)and insulin resistance.After adjustment for potential confounders, serum Fetuin-B was significantly associated with increased risks of metabolic syndrome and insulin resistance(OR=1.19,95%CI 1.06-1.34,P=0.004;OR=1.15,95%CI 1.01-1.30,P=0.031 respectively).Conclusion Serum Fetuin-B level was significantly associated with NAFLD;and elevated serum Fetuin-B was significantly associated with increased risk of metabolic syndrome.
