Glucagon like peptide-1 regulates appetite via specific nuclei in the central nervous system
10.3760/cma.j.issn.1000-6699.2018.02.019
- VernacularTitle:胰升糖素样肽1通过特定脑神经核团调节食欲
- Author:
Song WEN
1
;
Wenze XIAO
;
Jianlan JIN
;
Min GONG
;
Ligang ZHOU
Author Information
1. 复旦大学附属浦东医院内分泌科
- Keywords:
Glucagon like peptide-1;
Food intake;
Hypothalamus;
Food rewarding center
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(2):174-180
- CountryChina
- Language:Chinese
-
Abstract:
Glucagon like peptide-1(GLP-1) is a category of peptide secreted by intestine. The finding of GLP-1 was originated from the observation of "Incretin" phenomenon in 1960s. Besides lowering plasma glucose, GLP-1 can protect pancreas,improve cardiovascular outcome,and play a role in regulating appetite,as well as lower body weight. Given that food intake regulation mechanism modulated by GLP-1 remains uncertain,it is postulated that the central nervous system has played a vital role in this mechanism. In the present review,we focused on the following aspects about central nervous system's role in GLP-1's regulation of appetite:(1)The brain nuclei related to appetite regulation;(2) The brain nuclei related to blood glucose regulation; (3) The brain nuclei related to food intake reward behavior;(4) the role of food-related peptides and GLP-1;(5) How the GLP-1 receptor expression nuclei regulates the food intake.
