Effective GnRH analogue treatment and persistent remission of postmenopausal gonadotropin dependent hyperandrogenism: one case report and literature review
10.3760/cma.j.issn.1000-6699.2018.01.011
- VernacularTitle:GnRH类似物治疗绝经后促性腺激素依赖性高雄激素血症持续缓解一例并文献复习
- Author:
Xi WANG
1
;
Jianping XU
;
Zhaoxiang LIU
;
Jiangfeng MAO
;
Junjie ZHENG
;
Xueyan WU
Author Information
1. 100730 中国医学科学院,北京协和医学院,北京协和医院内分泌科,国家卫生和计划生育委员会内分泌重点实验室
- Keywords:
Postmenopausal hyperandrogenism;
Hirsutism;
Gonadotropin releasing hormone analogue
- From:
Chinese Journal of Endocrinology and Metabolism
2018;34(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
A retrospective study was conducted on one patient with postmenopausal hyperandrogenism. The postmenopausal female patient was found with significant hyperandrogenism ( total testosterone 6. 4 nmol/ L) and hirsutism, with normal adrenal androgen ( dehydroepiandrosterone-sulfate ) level. Computed tomography and ultrasound did not detect any ovarian and adrenal mass. Positron emission tomography revealed without high metabolic region, either. Ovarian and adrenal vein catheterization did not reveal any positive result. Obviously, ovary-derived hyperandrogenism was highly suspected, but the patient still refused any surgical exploration. After a trial of a single dose of gonadotropin releasing hormone analogue(GnRHa) triptorelin, increased testosterone level returned to normal along with decreasing level of gonadotropin. Multiple doses were needed for maintenance of testosterone at normal level with the intervals of 2 ～ 12 months. This response to the treatment was consistent with that of gonadotropin dependent hyperandrogenism.
