A study on the IFIH1 gene polymorphism in children with type 1 diabetes in Tianjin area

VernacularTitle:天津地区儿童1型糖尿病IFIH1基因多态性研究
Author: Ling LYU ¹ ; Shuxiang LIN ; Jianbo SHU ; Long GAO ; Ying QIAN ; Yulian FANG ; Le HUANG
Author Information

1. 300134,天津市儿童医院内分泌科
Keywords: Children; type 1 diabetes mellitus; IFIH1 gene; Polymorphism; gene
From: Chinese Journal of Endocrinology and Metabolism 2018;34(1):50-52
CountryChina
Language:Chinese
Abstract: The blood samples of 102 type 1 diabetic children aged under 15 years and 127 normal children were collected and their genomic DNAs were extracted. The single nucleotide polymorphisms rs1990760 and rs35744605 of interferon induced with helicase C domain 1(IFIH1)gene were detected. The results showed that the allele of IFIH1 rs35744605 in diabetes group and control group was the wild type G allele. The frequency of IFIH1 rs1990760 A allele in diabetes group was higher than that in control group(22. 1％ vs 13. 0％ ,P=0. 015), suggesting that IFIH1 rs1990760 A allele is associated with type 1 diabetes in Tianjin area.