Effect of thoracic paravertebral block combined with general anesthesia on long-term quality of life in patients undergoing breast cancer surgery
10.3760∕cma.j.issn.0254-1416.2018.03.018
- VernacularTitle:胸椎旁神经阻滞联合全身麻醉对乳腺癌手术患者远期生存质量的影响
- Author:
Xu LI
1
;
Lijian PEI
;
Gang TAN
;
Zhiyong ZHANG
;
Yuguang HUANG
Author Information
1. 100730,中国医学科学院 北京协和医学院 北京协和医院麻醉科
- Keywords:
Thoracic vertebrae;
Nerve block;
Anesthesia;
general;
Breast neoplasms;
Quality of life
- From:
Chinese Journal of Anesthesiology
2018;38(3):324-327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of thoracic paravertebral block ( TPVB) combined with general anesthesia on the long-term quality of life in the patients undergoing breast cancer surgery. Methods A total of 156 patients, aged 18-64 yr, of American Society of Anesthesiologists physical statusⅠ or Ⅱ, undergoing breast cancer surgery, were randomly assigned to TPVB combined with general anes-thesia group (TPVB+GA group, n= 78) and general anesthesia group (GA group, n = 78), and the pa-tients in two groups were matched with a ratio of 1 : 1. In group TPVB+GA, propofol (target effect-site concentration 2. 5-4. 0 μg∕ml) was given by target-controlled infusion, and patients received either single or multiple injections (T1-T5 ) of TPVB under ultrasound guidance at 30 min before induction of general an-esthesia. Group GA inhaled 2. 0％-2. 5％ sevoflurane. The patients were followed up at 6 and 12 months after operation, postoperative chronic pain and chronic pain affecting daily life were assessed using the mod-ified Brief Pain Inventory, the development of neuropathic pain using neuropathic pain questionnaire-short form, and the development of long-term health-related quality of life by using the 12-item short-form scale. Results There was no significant difference in the incidence of chronic pain and chronic pain affecting dai-ly life, incidence of neuropathic pain or quality of life scale score at 6 and 12 months postoperatively be-tween the two groups (P>0. 05). Conclusion TPVB combined with general anesthesia exerts no effect on the long-term quality of life in the patients undergoing breast cancer surgery.
