Relationship between degree of brain injury during perioperative period of liver transplantation and postoperative cognitive dysfunction
10.3760/cma.j.issn.0254-1416.2018.02.003
- VernacularTitle:肝移植围术期脑损伤程度与患者术后认知功能障碍的关系
- Author:
Yanxing ZHAO
1
;
Ping CHI
;
Yinghao CAO
;
Zhefeng QUAN
;
Kejun PENG
;
Xin LI
;
Xiaodong GUO
;
Li SUN
;
Haiyang LU
;
Haili HE
;
Dongmei MA
Author Information
1. 中国中医科学院广安门医院麻醉科
- Keywords:
Liver transplantation;
Brain injuries;
Cognition disorders
- From:
Chinese Journal of Anesthesiology
2018;38(2):138-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the degree of brain injury during the perioperative period of liver transplantation and postoperative cognitive dysfunction (POCD).Methods Thirtythree patients,undergoing elective liver transplantation,were enrolled in this study.Before induction of anesthesia (T0),at 5 min before blocking the portal vein (T1),5 min after opening the portal vein (T2),5 min after opening the hepatic artery (T3),and at 24 h after surgery (T4),blood samples were collected from the central vein for determination of the serum concentrations of S1O0β protein and neuron-specific enolase (NSE) by enzyme-linked immunosorbent assay.Patients were divided into POCD group and control group (group C) according to whether POCD happened within 7 days after surgery.Results Compared with the baseline value at T0,the serum concentrations of S100β protein were significantly increased at T2 and T3,and the serum concentrations of NSE was increased at T3 (P＜0.05).There was no significant difference in serum concentrations of S100β and NSE at each time point between group POCD and group C (P＞0.05).Conclusion The degree of brain injury during the perioperative period of liver transplantation is not the dominant factor for the development of POCD in the patients.
