The characteristics and independent associated factors of positive surgical margin after radical prostatectomy
10.3760/cma.j.issn.1000-6702.2018.10.004
- VernacularTitle:根治性前列腺切除术后切缘阳性的临床特征和影响因素分析
- Author:
Huimin HOU
1
;
Xin JIANG
;
Ming LIU
;
Tongxiang DIAO
;
Jianye WANG
Author Information
1. 100730,北京协和医学院研究生院 北京医院泌尿外科
- Keywords:
Prostatic neoplasms;
Positive surgical margin;
Prostate imaging-reporting and data system score
- From:
Chinese Journal of Urology
2018;39(10):740-744
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the associated factors of positive surgical margin after radical prostatectomy.Methods A retrospective analysis was conducted on 320 patients who underwent radical prostatectomy from June 2007 to June 2017,whose age was 45-80 years(mean 67.9) and PSA was 0.05-123.19 ng/ml (mean 14.4ng/ml).The patients were divided into groups by age,PSA,PI-RADS score,clinical stage,biopsy Gleason score and operation approach.Chi-square test was used for single factor analysis and binary logistic regression analysis for multivariate analysis to evaluate the correlation between clinical and pathological data and positive cutting edge.Result Among the total 320 patients,there were 94 (29.4％) patients had positive surgical margin after radical prostatectomy.There were 26 (21.0％) positive surgical margin located at ventral sites,18(14.5％) located at dorsal sites,21 (16.9％) located at base,and 59(47.6％) located at tip.The positive rate of surgical margin was different in different positive areas of MRI (P ＜0.01),among which the MRI showed cancer located in the tip of prostate had the highest positive rate (47.6％) of surgical margin after prostatectomy.Univariate risk factor analysis was performed which showed that PSA(P =0.023),positive needle percentage (P =0.001),biopsy pathologic Gleason score(P =0.029),PI-RADS score (P =0.022) and prostate cancer risk score (P =0.006) had significant correlation with positive surgical margin.The age (P =0.257),clinical stage (P =0.161) and operation approch (P =0.260) had no significant correlation.Then multivariate analysis showed that PI-RADS score (P =0.023) and positive needle percentage (P =0.047) could be used as independent predictors of positive surgical margin.Conclusions PI-RADS score and percentage of positive biopsy needles were independent risk factors for positive surgical margin after prostatectomy.There was highest positive rate of surgical margin when MRI showed cancer located at the tip of prostate.
