The Effect of Topical Interferon alpha-2b in the Treatment of Conjunctival Squamous Papilloma.
- Author:
Ju Yeob KIM
1
;
Yoon Duck KIM
Author Information
1. Happy Eye Clinic, Korea.
- Publication Type:Original Article
- Keywords:
Interferon alfa-2b;
Squamous papilloma
- MeSH:
Biopsy;
Conjunctiva;
Follow-Up Studies;
Humans;
Interferons*;
Papilloma*;
Recurrence
- From:Journal of the Korean Ophthalmological Society
2006;47(11):1729-1734
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To study the effectiveness of Interferon alfa-2b (IFN alpha 2b) for treating squamous papilloma of the conjunctiva. METHODS: One million units/cc of IFN alpha 2b was applied 4 times a day after identifying squamous papilloma by excisional biopsy. The IFN alpha 2b was used continuously 2 to 6 months after the tumor became undetectable with the unaided eye. The dose was then tapered. RESULTS: Three of the 4 patients had a history of recurrences (1-4 times). In one patient, the tumor was difficult to remove surgically due to the location of the tumor (around the upper punctum). The tumor disappeared with no complications or recurrences during the follow-up period. CONCLUSIONS: In patients with conjunctival squamous papilloma with frequent relapses or difficulty in excision, applying IFN alpha 2b as an eye drop appears to be an effective form of therapy and can be used safely without complications.
