The glucocerebrosidase gene and Parkinson's disease
10.3760/cma.j.issn.0254-9026.2018.10.027
- VernacularTitle:葡糖脑苷脂酶基因与帕金森病
- Author:
Si LUO
1
;
Jiajun CHEN
;
Lei ZHANG
Author Information
1. 吉林大学中日联谊医院神经内科
- Keywords:
Cerebrosidaes;
Alpha-synuclein;
Parkinson's disease
- From:
Chinese Journal of Geriatrics
2018;37(10):1169-1172
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD) is a common neurodegenerative disease afflicting many older individuals.To date,mutations in the GBA gene is considered as a major risk factor for PD,but the underlying mechanism is still unclear.Glucocerebrosidase (GCase) encoded by GBA may work as a biomarker for the early diagnosis of PD associated with GBA mutations (PD-GBA).Increasing GCase enzyme activity or reducing its substrate availability may protect the neuron and slow the progression of PD-GBA.
