The relationship between gut microbiota and Parkinson's disease
10.3760/cma.j.issn.0254-9026.2018.10.026
- VernacularTitle:肠道菌群与帕金森病的相关性
- Author:
Mingyang HU
1
;
Biao CHEN
Author Information
1. 100053,首都医科大学宣武医院国家老年疾病临床医学研究中心
- Keywords:
Parkinson's disease;
Microbiota;
Moleculer mimicry
- From:
Chinese Journal of Geriatrics
2018;37(10):1164-1168
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease (PD) is the second most common neurodegenerative disorder.Its clinical symptoms and evidence of neuropathology indicate that PD may start from the gut.Besides,there are a large amount of microbiota colonies in the gut,whose dysbiosis may play an important role in the onset and development of PD.This article focuses on the relationship between PD and the gut microbiota based on reviewing literatures on the correlation between the gut microbiota and PD published in the last ten years,and on exploring their underlying relationship.The characteristic changes in dysbiosis of the gut microbiota in PD patients are not clearly known.Based on previous studies,mechanism of dysbiosis of gut microbiota in PD may include inflammation,disruption of the barriers,a-Syn and so on.They may synergetically interact each other rather than acting as independent factors.Among them,the molecular simulation may play an important role in the relationship between gut microbiota and PD.More studies on the mechanism of the relationship between the gut microbiota and PD are needed to improve the early diagnosis and treatment of PD.
