Association between herpes simplex virus infection and atrial fibrillation in elderly individuals
10.3760/cma.j.issn.0254-9026.2018.10.004
- VernacularTitle:单纯疱疹病毒感染与老年人心房颤动的相关性研究
- Author:
Nian LIU
1
;
Shaowei LIU
;
Linling LI
;
Qianqian ZHAO
;
Songnan WEN
;
Yanfei RUAN
;
Xin LI
;
Songnan LI
;
Deyong LONG
;
Ribo TANG
;
Ronghui YU
;
Xin DU
;
Jianzeng DONG
;
Changsheng MA
Author Information
1. 100029,首都医科大学附属北京安贞医院心内科
- Keywords:
Atrial fibrillation;
Simplex virus;
C-reactive protein
- From:
Chinese Journal of Geriatrics
2018;37(10):1078-1081
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate associations of herpes simplex virus(HSV)infection with elevated high-sensitivity C-reactive protein(hsCRP)level and the development of atrial fibrillation(AF) in elderly individuals.Methods Through screening a total of 2,603 individuals,49 patients aged 60 years or over with AF and without structural heart diseases and known risk factors for AF were selected for data collection.Fifty-five elderly healthy control subjects were selected from a population based Chinese Arrhythmia Registry.Baseline characteristics,plasma antibody levels against HSV-1 and-2,and level of hsCRP were analyzed.Results Level of antibodies against HSV-1 was significantly higher in AF patients[(314.5±63.6)mg/L than in control subjects(216.0±50.7) mg/L,P＜0.01].Level of antibodies against HSV-2 was significantly higher in AF patients[(400.1±50.7) mg/L than in control subjects (306.3 ± 64.5) mg/L,P ＜ 0.01].Linear regression analysis demonstrated a positive correlation of plasma levels of hsCRP with both anti-HSV-1 and anti-HSV-2 IgG antibodies (r =0.291,0.188,all P ＜ 0.01).In multiple logistic regression analysis,HSV-1 and HSV-2 antibody levels were significantly associated with AF occurrence(OR =1.035 and 1.034,all P ＜0.01).The optimal cut-off point for predicting AF occurrence was 284.96 mg/L for anti-HSV-1 with sensitivity of 67.3％ and a specificity of 92.7％,and was 366.26 mg/L for anti-HSV-2 with a sensitivity of 67.3％ and a specificity of 85.5％,respectively.Conclusions The increased plasma levels of anti-HSV-1 and anti-HSV-2 antibodies are significantly associated with AF occurrence in elderly adults.
